vii Is important to leave clearly that so far in we relate to the plant or the leaf to them, whose effect in the organism is not compared with the effect stimulant of its active principle, the cocaine. It was only in 1860 that German chemistry Albert Niemann, it isolated the pure active principle, or the main alkali, that was called of cocaine viii. At the beginning the cocaine appeared as a great advance for medicine. Beyond stimulant, he was used as anaesthetic. The discovery of the cocaine was published in the main medical magazines, as much of the Europe as of the United States; an incapable product was about secondary damages.
The cocaine was used for the treatment of the depression, tooth aches, throat, in oftalmolgicas surgeries and treatment of chemical dependence. Also it has stories of cure of the dependence of the opium through the cocaine. ix In the second half of century XIX, starts to appear in the pharmaceutical market, the first products the base of the cocaine leaf or with the active principle, the cocaine. Amongst these products we have: tablets to alliviate to dental pains, tonic and alcoholic beverages and not-alcoholic. Amongst these products, the Wine of Mariani Cocaine is distinguished, that stimulated the manufacture of Coca-Cola, developed for the North American boticrio John Stith Pemberton. x Pemberton (1831-1888) was a boticrio, owner of a pharmacy in Atlanta, had invented a called tonic French Wine Glue, that was constituted to the base of alcohol and leves of cocaine and glue nut xi, similar to the wine of Mariani cocaine, much appreciated in the Europe. The problem was that the Mariani wine was constituted basically of the wine of Bordeux, that if becomes expensive in the United States. Of this form, Pembertom decided to remove of the formula the wine. xi Coca-Cola, as came to be called, was vendida as plus one of ' ' milagrosos' ' tonics to fight a series of males as the nervous chronic headache, depressions, loss of heart and indisposio xiii.